生物活性：Tacrolimus-13C,d2 is a 13C-labeled and deuterium labeled Tacrolimus. Tacrolimus (FK506), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties[1].
IC50 & Target：Macrolide
體外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
瑞禧生物 has not independently confirmed the accuracy of these methods. They are for reference only.
Tacrolimus-13C,d2 相關(guān)抗體:
PFKFB3 Antibody
FKBP12 Antibody
FKBP51 Antibody
FKBP52 Antibody
DUSP1 Antibody
DUSP3 Antibody
MRP2 Antibody
Elongation factor 2 Antibody (YA962)
Elongation factor 2 Antibody (YA964)
PU.1/SPI1 Antibody (YA1116)
Intestinal Alkaline Phosphatase Antibody (YA1559)
PFKL Antibody (YA1597)
SHP2 Antibody (YA1643)
PP1C alpha/beta Antibody (YA1700)
PTP1B Antibody (YA1776)
PLEKHA1 Antibody (YA2145)
PGAM1 Antibody (YA2156)
DUSP6 Antibody (YA2280)
FKBP38 Antibody (YA2803)
PRAS40 Antibody (YA3179)
PPP4C Antibody (YA687)
Sulfadimidine Antibody (YA906)
Elongation factor 2 Antibody (YA963)
Phospho-PTP1B (Ser352) Antibody (YA1027)
Phospho-PTP1B (Ser378) Antibody (YA1028)
Placental Alkaline Phosphatase Antibody (YA1038)
Placental Alkaline Phosphatase Antibody (YA1039)
PP1C alpha Antibody (YA1040)
PP1C alpha Antibody (YA1041)
SHP1 Antibody (YA1044)
分子量：807.02
Formula：C4313CH67D2NO12
CAS 號(hào)：1356841-89-8
非標(biāo)記 CAS：104987-11-3
性狀：固體
顏色：White to yellow
中文名稱：他克莫司 13C,d2
運(yùn)輸條件：Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式：Powder：-20°C：3 years，4°C：2 years
In solvent：-80°C：6 months，-20°C：1 month
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